Fast Asleep 911™ by Phytage Laboratories

Calcium

Brain Calcium Controls How Long We Sleep
We know calcium is good for our bones, but it might also be the key to a good night sleep. Researchers at the RIKEN Quantitative Biology Center (QBiC) and the University of Tokyo in Japan have unveiled a new theory for how sleep works. Published in the journal Neuron, the work shows how slow-wave sleep depends on the activity of calcium inside neurons.
https://www.eurekalert.org/pub_releases/2016-03/r-bcc031416.php

Diet and Sleep Physiology: Public Health and Clinical Implications
Micronutrients intake have also been suggested to affect sleep patterns. For example, associations have been reported for deficiencies in vitamin B1, folate, phosphorus, magnesium, iron, zinc, and selenium with shorter sleep duration, lack of alpha-carotene, selenium, and calcium with difficulty falling asleep, low intake of vitamin D and lycopene with sleep maintenance, and low intake of calcium and vitamin C with non-restorative sleep.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554513/

Vitamin B6

Natural Treatments for Insomnia
Impaired brain serotonin production – may be related to cofactor insufficiency (Vitamin B6 and zinc) or magnesium deficiency (magnesium is required for phosphorylation of pyridoxine into its active form pyridoxal-5-phosphate). Impaired ability to relax – often related to chronic stress, which is associated with increased need for Vitamin B3 and Vitamin B6.
https://www.psychologytoday.com/us/blog/sleep-newzzz/201905/5-ways-vitamin-deficiencies-can-impact-your-sleep

Vitamins and Sleep: These Vitamins Deficiencies Can Cause Sleep Trouble
Vitamin B6 helps your body take tryptophan and turn it into serotonin, a key hormone that helps with everything from feeling happy to getting good rest. It can help you sleep better and wake up feeling more rested. Fish is a great source of B6, but you can also get it from spinach, bananas, whole grains, chickpeas, and carrots if you’re vegetarian or vegan.
https://www.venturacwc.org/vitamins-and-sleep/

Magnesium

Magnesium Intake and Sleep Disorder Symptoms
In clinical trials, dietary magnesium use can improve insomnia symptoms. However, little is known about the association between dietary magnesium consumption and sleep disorder symptoms including daytime falling asleep, sleepiness and snoring at the population level.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212970/

Melatonin

The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature
Exogenous melatonin, as both prescription and over the counter pills/tablets, has become one of the most frequently requested non-prescription sleep aids due to its regulator role in the internal timing of biological rhythms, including promotion/regulation of sleep. Melatonin is marketed to help promote total sleep time, aid with fatigue from jet lag, or balance circadian rhythms from jet lag and rotating shift work. Evidence suggests melatonin may reduce the time it takes for people with delayed sleep phase syndrome (i.e., sleep is delayed by two or more hours beyond the conventional bedtime, causing difficulty in waking at a desired time) to fall asleep; melatonin may also help reset the body’s sleep-wake cycle. Importantly, melatonin has been shown to serve as a mediator between the thermoregulatory and arousal system in humans, such that exogenous administration of melatonin during the day can result in sleepiness in association with reduced core temperature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273450/

L-tryptophan

Analysis, Nutrition, and Health Benefits of Tryptophan
Lieberman used available data for 29 687 US adults to determine the effect of the average daily intake of 826 mg/d of tryptophan on liver and kidney function, depression, and sleep outcomes. The authors conclude that the high intake of tryptophan does not seem to affect liver and kidney function or carbohydrate metabolism but was inversely associated with the self-reported level of depression and positively associated with sleep duration. In a related investigation, Bravo analyzed whether consumption of cereals enriched with tryptophan might facilitate the reconsolidation of the sleep/wake cycle and counteract depression and anxiety. In the study by Wenefrida, middle-aged/elderly individuals consumed standard cereals with a tryptophan content of 22.5 mg/30 g at breakfast and dinner in the control and cereals with a tryptophan content of 60 mg/30 g in the treatment week. The results show that consumption of the higher tryptophan cereals increased sleep efficiency and sleep time and improved anxiety and depression symptoms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158605/

Goji

A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi
This randomized, double-blind, placebo-controlled clinical trial is the first study reported from outside China that has examined the general effects of the orally consumed goji berry, Lycium barbarum, as a standardized juice (GoChi; FreeLife International LLC, Phoenix, AZ) to healthy adults for 14 days. Significant differences between day 1 and day 15 were found in the GoChi group (N = 16) in increased ratings for energy level, athletic performance, quality of sleep, ease of awakening, ability to focus on activities, mental acuity, calmness, and feelings of health, contentment, and happiness.
https://pubmed.ncbi.nlm.nih.gov/18447631/

Chamomile

An Herbal Medicine of the Past With a Bright Future
Traditionally, chamomile preparations such as tea and essential oil aromatherapy have been used to treat insomnia and to induce sedation (calming effects). Chamomile is widely regarded as a mild tranquilizer and sleep-inducer. Sedative effects may be due to the flavonoid, apigenin that binds to benzodiazepine receptors in the brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/

Lemon Balm

"Sleep Promoting Effects of IQP-AO-101: A Double-Blind, Randomized, Placebo-Controlled Exploratory Trial
The history of plant-derived sleep aids goes back as far as ancient times. Plants such as valerian (Valeriana officinalis L.), hops (Humulus lupulus L.), passion flower (Passiflora incarnata L.), lavender (Lavandula officinalis L.) or lemon balm (Melissa officinalis L.) have been used by healers to reduce anxiety, induce calmness, and promote sleep. Since medicinal plants are made up of a variety of constituents that exert different beneficial properties that may help to combat sleep problems, different herbs are often combined to achieve synergistic effects. However, solid evidence of their efficacy is lacking for many natural products available on the market. To date, clinical trials in humans provide preliminary evidence for only a few herbal sleep aids, such as valerian, passion flower or lemon balm.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521387/

Passionflower

Effect of a medicinal plant (Passiflora incarnata L) on sleep
In research, Passiflora incarnata induced a significant increment in the total sleep time (p <0.05). Concomitantly, a significant decrement in wakefulness (W) was observed (p<0.05). In contrast, time spent in rapid eye movement (REM) sleep showed a decreasing tendency, since both its frequency and mean duration were reduced.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699852/

L-Taurine

Effect of Taurine and Caffeine on Sleep-Wake Activity in Drosophila Melanogaster
Treatment with taurine at 0.1% to 1.5% reduces locomotor activity by 28% to 86% and shifts it from diurnal to nocturnal. At 0.75%, taurine also increases total sleep by 50%. Our results show that taurine increases sleep, while caffeine, as previously reported, attenuates sleep.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630960/

Hops

Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electro hypnograms
Repetitive administrations of valerian/hops combinations have been widely used for self-administered therapy of sleep disturbances.
https://pubmed.ncbi.nlm.nih.gov/18559301/